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About 12 years ago my doctor found out that the level of uric acid in my blood was above normal. Soon afterwards I started having gout attacks and felt myself an old helpless ass. But my doc, a nice young lady, prescribed me with Allopurinol. It has been 10 years since I started taking the pills and I'm still damn grateful to my wonderful doctor!
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30 year old male. had gout for 1 year. 1st attack so bad that it developed tophi in my big toe joint. Uric acid was 9.6 at the time. Made some diet changes but that only brought me down to 7.4. I have gout attacks quite often, but most are mild. Ive been on 100mg allopurinol for a month with no side effects. Uric acid is now 6.2 so I had my dosage increased to 200mg so I can get below 6. It is very important to get on daily colchicine (0.6mg twice a day) while starting allopurinol. I learned the hard way.

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This is to see whether the levels of uric acid are going down with the allopurinol treatment, and by how much.

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We performed a sensitivity analysis where there was concern about risk of bias of an included non-randomised CCT, and this showed no overall difference.

Besides this thorough examination of the drugs ingredients and performance, the FDA also conducts periodic inspections of the manufacturing plants to ensure there are no changes in the approved drugs quality.

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